Botulinum toxin for hyperhidrosis?

Thursday, March 5, 2009

Botulinum toxin for hyperhidrosis?

http://curesweatypalms.com/Botulinum-toxin-for-hyperhidrosis.htm

Clinical bottom lineOn the basis of limited information from four randomised studies, botulinum toxin appears to be effective for hyperhidrosisSeveral strains of botulinum toxin exist, the most commonly used in medicine are botulinum toxin A and B. Botulinum toxin A is commercially manufactured as Botox and Dysport. These are different agents, with one mouse unit of botox being approximately equivalent to three mouse units of dysport. The toxin is licensed as a treatment for a number of indications, mainly dystonias and spasm, but is also commonly used for cosmetic reasons to reduce the effects of ageing. When injected into muscle the toxin blocks the release of acetylcholine at the neuromuscular junction. This reduces muscle tone, which alleviates symptoms. It has been assumed that botulinum toxin will also inhibit other cholinergic mechanisms, such as sweat production. Hyperhidrosis is a rare condition in which large quantities of water and electrolytes are exuded from the body. In severe cases, hands and feet may drip with secretions. The condition has a considerable emotional and social burden. When other treatments have failed, surgical intervention is possible but the risk of compensatory sweating in other areas exists. Another possibility is to use botulinum toxin.SearchPubMed was searched for randomised, double blind, controlled trials of botulinum toxin for the treatment of hyperhidrosis. Free text terms included 'botulinum toxin', 'botox', 'dysport' and 'hyperhidrosis'.ResultsSeveral studies were identified of which four [1-4] were randomised and double blind and details of these are shown in Table 1 (bottom of page). Three of the four trials scored highly with a commonly used 5-point quality scoring system [Jadad et al, 1996], though they differed in the type of botulinum toxin A, dose, number of injections, duration of observations, and choice of outcome.Two trials [Naumann et al, 2001; Schnider et al, 1999] were conducted in patients with axillary hyperhidrosis over 13 and 16 weeks, and two studies conducted over four and 13 weeks were in patients with palmer hyperhidrosis.Outcome data were presented in slightly difference ways in the trials, but all showed greater improvement (reduction in sweating) with botulinum toxin A than with placebo. The largest study [Naumann et al, 2001] reported greater than 50% reduction in axillary sweating from baseline in 198/242 (82%) patients given botulinum toxin and 16/78 (21%) given placebo at 16 weeks. The additional benefit achieved with toxin over that achieved with placebo was 61%, suggesting an NNT of less than 2. Patient global ratings in this study were equivalent to moderate improvement. If information for vaguely similar outcomes is pulled together across other trials an improvement of roughly 30% is shown with botulinum toxin over that occurring with placebo. This could also be regarded as moderate improvement.Adverse events were relatively uncommon. To note though is that two patients with severe and socially limiting axillary hyperhidrosis experienced increased palmer sweating after treatment with botulinum toxin. Since the toxin decreases muscle tone it is possible that grip strength could be reduced in patients with palmer hyperhidrosis, but there was no evidence of this in the trial by Lowe and colleagues.CommentThe results are interesting but should be interpreted with caution. The main caveat is that there are limited data at present. With one exception, the studies were small and used within patient comparisons. That doses and outcomes differed also muddies the waters, and it is difficult to say whether the effects of the toxin are greater with increased dose. It does appear, though, that botulinum toxin reduces symptoms in this rare condition. The report of increased palmer sweating in patients with axillary hyperhidrosis should be noted, and it was not reported in the trial whether this subsided as the effects of treatment wore off.There will be issues of patient selection, since the site and number of injections required will impact on the feasibility and acceptability of treatment. At present this is an off-license indication for botulinum toxin. It does not provide a cure, and repeated injections would be required to limit symptoms in the long-term. In patients with palmer hyperhidrosis, another consideration might be the long-term effects on muscle tone.References
Lowe NJ et al. Efficacy and safety of botulinum toxin type A in the treatment of palmer hyperhidrosis: a double-blind, randomised, placebo-controlled study. Dermatologic Surgery 2002;28:822-27.
Neumann N et al. Botulinum toxin type A in treatment of bilateral primary axillary hyperhidrosis: randomised, parallel groups, double blind, placebo controlled trial. BMJ 2001; 325:1-4
Schnider P et al. A randomised, double-blind, placebo-controlled trial of botulinum toxin for severe axillary hyperhidrosis. British Journal of Dermatology 1999;140:677-680.
Schnider P et al. Double-blind trial of botulinum A toxin for the treatment of focal hyperhidrosis of the palms. British Journal of Dermatology 1997; 136: 548-552.
Jadad A et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Controlled Clinical Trials. 1996; 17:1-12.

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Severe Hyperhidrosis Read more hyperhidrosis article

HYPERHIDROSIS OR EXCESSIVE SWEATING
What is hyperhidrosis Where does hyperhidrosis occur What are the symptoms of hyperhidrosis What are the alternative treatments for hyperhidrosis Is there a surgical treatment for hyperhidrosis

LINKS
1 Cosmetic Surgery Center Control Excessive Sweating The Cure Foot Pain Center Cure Hand Pain Center Cure Hyperhidrosis Center The Center For Lover-For-Life Hemorrhoid Treatment Center Woman Wellness Center The Hyperhidrosis Center Doctor's Outpatient Surgery Center The Veins Treatment Center

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Cure Hyperhidrosis

People come from around the world to the Center for the Cure of Sweaty Palms to consult with Dr. Fritz Baumgartner, an expert in the cure of palmar hyperhidrosis (sweaty palms), axillary hyperhidrosis (sweaty underarms), and plantar hyperhidrosis (sweaty feet). Dr. Fritz J. Baumgartner, Board Certified by the American Board of Surgery and the American Board of Thoracic Surgery, is the foremost leader in his field. He is a recipient of "AMERICA'S TOP SURGEONS" award for 2002-2003 and 2004-2005, and "AMERICA'S TOP PHYSICIANS" award for 2004-2005. Dr. Baumgartner utilizes the most advanced, minimally-invasive, endoscopic techniques to cure hyperhidrosis by using micro incisions that reduce muscle and tissue disruption.
KLSX Interview with Dr. Fritz Baumgartner on hyperhidrosis.
For the Best of California Video on hyperhidrosis.
For a Presentation on hyperhidrosis.
Take a Virtual Tour of our center
Server Hyperhidrosis by Dr. Baumgartner
Orange Coast Article
Hyperhidrosis Article
Hyperhidrosis is a condition of excessive sweating. This is a medical condition caused by an overactivity of the sympathetic nervous system of the sweat glands. The only effective medical treatment for severe hyperhidrosis is a surgical procedure called Endoscopic Thoracic Sympathectomy or, ETS. This operation can now be performed safely as an outpatient, same-day procedure. There is very little bleeding involved, which reduces recovery time, minimizes scarring, and contributes to less post-operative pain. Patients enjoy quality results, immediately! Read More on Hyperhidrosis

Axillary Hyperhidrosis

Axillary Hyperhidrosis involves extreme, dripping sweat in the armpits, with constant odor that is usually resistant to all deodorants. Axillary sweating may be present, alone, or in conjunction with any or all other types of hyperhidrosis. Sufferers are prevented from wearing certain fabrics and colors because the sweat causes staining and rotting of the clothing. The sympathetic nervous system over-stimulates the sweat glands, causing the hyperhidrosis. This condition may be aggravated by anxiety, but it can occur without it. Each patient has to be evaluated individually, to determine if they are candidates for the ETS procedure. Read more on Axillary Hyperhidrosis
Facial Hyperhidrosis

Facial Hyperhidrosis Individuals with Severe Facial Blushing characteristically experience a glowing red face that occurs more frequently and last longer than normal blushing. The blushing (Erythrophobia) is intense, constant and lasts for a prolonged period of time. Prior to onset, patients usually experience intense facial heat. The face and neck will usually glow a bright red color. Find out more on Facial Blushing
Palmar Hyperhidrosis
Sweaty palms is a condition referred to as palmar hyperhidrosis. This medical condition is caused by hyperactive sympathetic nervous activity over sweat glands of the hands. Medical treatment typically consists of prescription medication, which only reduces sweating temporarily, and is not normally effective in severe cases of this condition. The only effective treatment for patients with server palmar hyperhidrosis is a surgical procedure called thoracoscopic sympathectomy. This procedure can now be performed safely as an outpatient, same day basis...Read More on Sweaty Palms
Plantar Hyperhidrosis

Plantar Hyperhidrosis, severe sweating of the feet, usually occurs in conjunction with Palmar Hyperhidrosis, hand sweating, as a result of an overactive sympathetic nervous system. People with Plantar Hyperhidrosis complain of bad foot odor. The most common problems with Plantar Hyperhidrosis are athlete’s feet, blisters, infection and rotting of socks.Read More on Sweaty Feet
Testimonials of Hyperhidrosis

Dear Dr.Baumgartner and the Center For The Cure of Sweaty Palms™, I suffered from hyperhydrosis(hyperhidrosis) in my hands and feet from birth, an embarrassment that hindered me in many ways. Whether facing an introduction or a dance lesson, I feared contact with other people because I always received the same negative responss--"Gross! What's wrong with you? Why are your hands wet?" I remember giving a presentation in front of the class in 5th grade and watching in horror as my hands literally dripped to the floor with sweat, not due to nerves but because of the hyperhydrosis. Read More Hyperhidrosis Testimonials From Around the World
Hyperhidrosis is a physical condition caused by excessive sweating in the body. Hyperhidrosis is caused due to malfunctioning of the sympathetic nervous system or disorders of the sweat glands. Curesweatyplams provides the best excessive perspiration treatment. Though excessive sweating causes are many the primary causes are still unknown and the secondary causes range from anxiety, obesity and psychological tension. Hyperhidrosis symptoms can be dripping sweat, odor along with sweat, stained clothes due to sweat and inferiority complex due to sweat. There are many types of hyperhidrosis like palmer hyperhidrosis, excessive foot sweating, severe underarm sweating and facial hyperhidrosis. Hyperhidrosis can occur at any age. Normally excessive sweating problem occurs after adolescence but there is surgery to stop sweating, which is described at curesweatypalms. Hyperhidrosis medication at an older age is tougher as many other things have to be kept in mind like blood pressure, allergies and resistance. Hyperhidrosis or profuse sweating can be cured with BOTOX injection and Drysol but these medicinal treatments for hyperhidrosis cannot undo the physiological damage that it does to an individual. Excessive perspiration leads the sufferer to isolate from social gatherings and meeting people to avoid embarrassment. Girls sweating or women’s sweaty feet normally cause them a lot of shame.Excess armpit sweating can be treated with hyperhidrosis medication like iontophoresis, sympathectomy, thoracic surgery, botox cosmetic and drysol. Botox is Botulinum Toxin of Type A and is commonly used as treatment fro excessive sweating. Though drysol is also a remedy for hyperhidrosis but there are side effects of drysol which many it a bit less popular and hyperhidrosis botox are named together. Many people suffer from hyperhidrosis like profuse facial sweating, armpit sweating, sweating armpits, sweating at night. They are mostly those who work as speaker or those who address a big audience. On the whole anybody can suffer from hyperhidrosis but those people who are under constant anxiety and tension are at more risk. Jobs like those of models, television personalities, chefs, executives, attorneys, and salesmen are seen to be suffering from intense sweating. These people should refer to curesweatyplams and take treatments for hyperhidrosis like hyperhidrosis surgery, thoracic surgery procedure and surgery for sweaty hands. The maximum population suffers from underarm sweating, which is also called axillary hyperhidrosis. Many people log on to curesweatyplams and say stop sweating under the arms or stop my underarm sweating. Sweaty underarms can be cured but the worst hit are those who have excessive armpit sweating along with a bad odor. But curesweatyplams gives information on surgery to stop sweating. Though sometimes the skin from which the sweat glands are removed or treated reacts to the medicine but it heals with time. Overactive sweat glands can be cured at any age but a proper qualified doctor should be consulted and curesweatyplamsprovides you with all the essential information. Sweaty hands and feet are a big problem and cause much stress but if treated properly can be cured permanently. You need the best and curesweatyplams is the best in dealing with hyperhidrosis.

GENERAL INFORMATION
Home Q&A Questionnaire Payment Methods Testimonials Disclaimer FAQ

CONTACT US
Email Us Our Address Local Direction Local Accommodations Local Attractions

SURGEON'S PROFILE
Doctor Baumgartner Memberships Curriculum Vitae Appointment Hospital Affiliation Bibliography Books And Book Chapters Abstracts Presented & Published

HYPERHIDROSIS INFORMATION
Hyperhidrosis Symptoms of hyperhidrosis Axillary Hyperhidrosis Palmar Hyperhidrosis Plantar Hyperhidrosis Medical Treatment Surgical Technique Surgical Preparation Post Operative Results Side Effects Complications Surgical Sweating Treatment Procedure ETS Surgical Preparation Post Operative Hyperhydrosis Results Side Effects Complications

BROCHURES
Request Form Brochures in Spanish Brochures in Vietnamese

ARTICLES
Severe Hyperhidrosis Read more hyperhidrosis article

HYPERHIDROSIS OR EXCESSIVE SWEATING
What is hyperhidrosis Where does hyperhidrosis occur What are the symptoms of hyperhidrosis What are the alternative treatments for hyperhidrosis Is there a surgical treatment for hyperhidrosis

LINKS
1 Cosmetic Surgery Center Control Excessive Sweating The Cure Foot Pain Center Cure Hand Pain Center Cure Hyperhidrosis Center The Center For Lover-For-Life Hemorrhoid Treatment Center Woman Wellness Center The Hyperhidrosis Center Doctor's Outpatient Surgery Center The Veins Treatment Center

Cure Hyperhidrosis

Millions of Americans Suffer from Hyperhidrosis. You are not alone!Make an appointment. The cure is just a phone call away.Call us Toll Free:1 (866) PALM 911 or 1 (866) 725 - 6911

Cure Hyperhidrosis

People come from around the world to the Center for the Cure of Sweaty Palms to consult with Dr. Fritz Baumgartner, an expert in the cure of palmar hyperhidrosis (sweaty palms), axillary hyperhidrosis (sweaty underarms), and plantar hyperhidrosis (sweaty feet). Dr. Fritz J. Baumgartner, Board Certified by the American Board of Surgery and the American Board of Thoracic Surgery, is the foremost leader in his field. He is a recipient of "AMERICA'S TOP SURGEONS" award for 2002-2003 and 2004-2005, and "AMERICA'S TOP PHYSICIANS" award for 2004-2005. Dr. Baumgartner utilizes the most advanced, minimally-invasive, endoscopic techniques to cure hyperhidrosis by using micro incisions that reduce muscle and tissue disruption.
KLSX Interview with Dr. Fritz Baumgartner on hyperhidrosis.
For the Best of California Video on hyperhidrosis.
For a Presentation on hyperhidrosis.
Take a Virtual Tour of our center
Server Hyperhidrosis by Dr. Baumgartner
Orange Coast Article
Hyperhidrosis Article
Hyperhidrosis is a condition of excessive sweating. This is a medical condition caused by an overactivity of the sympathetic nervous system of the sweat glands. The only effective medical treatment for severe hyperhidrosis is a surgical procedure called Endoscopic Thoracic Sympathectomy or, ETS. This operation can now be performed safely as an outpatient, same-day procedure. There is very little bleeding involved, which reduces recovery time, minimizes scarring, and contributes to less post-operative pain. Patients enjoy quality results, immediately! Read More on Hyperhidrosis

Axillary Hyperhidrosis

Axillary Hyperhidrosis involves extreme, dripping sweat in the armpits, with constant odor that is usually resistant to all deodorants. Axillary sweating may be present, alone, or in conjunction with any or all other types of hyperhidrosis. Sufferers are prevented from wearing certain fabrics and colors because the sweat causes staining and rotting of the clothing. The sympathetic nervous system over-stimulates the sweat glands, causing the hyperhidrosis. This condition may be aggravated by anxiety, but it can occur without it. Each patient has to be evaluated individually, to determine if they are candidates for the ETS procedure. Read more on Axillary Hyperhidrosis
Facial Hyperhidrosis

Facial Hyperhidrosis Individuals with Severe Facial Blushing characteristically experience a glowing red face that occurs more frequently and last longer than normal blushing. The blushing (Erythrophobia) is intense, constant and lasts for a prolonged period of time. Prior to onset, patients usually experience intense facial heat. The face and neck will usually glow a bright red color. Find out more on Facial Blushing
Palmar Hyperhidrosis
Sweaty palms is a condition referred to as palmar hyperhidrosis. This medical condition is caused by hyperactive sympathetic nervous activity over sweat glands of the hands. Medical treatment typically consists of prescription medication, which only reduces sweating temporarily, and is not normally effective in severe cases of this condition. The only effective treatment for patients with server palmar hyperhidrosis is a surgical procedure called thoracoscopic sympathectomy. This procedure can now be performed safely as an outpatient, same day basis...Read More on Sweaty Palms
Plantar Hyperhidrosis

Plantar Hyperhidrosis, severe sweating of the feet, usually occurs in conjunction with Palmar Hyperhidrosis, hand sweating, as a result of an overactive sympathetic nervous system. People with Plantar Hyperhidrosis complain of bad foot odor. The most common problems with Plantar Hyperhidrosis are athlete’s feet, blisters, infection and rotting of socks.Read More on Sweaty Feet
Testimonials of Hyperhidrosis

Dear Dr.Baumgartner and the Center For The Cure of Sweaty Palms™, I suffered from hyperhydrosis(hyperhidrosis) in my hands and feet from birth, an embarrassment that hindered me in many ways. Whether facing an introduction or a dance lesson, I feared contact with other people because I always received the same negative responss--"Gross! What's wrong with you? Why are your hands wet?" I remember giving a presentation in front of the class in 5th grade and watching in horror as my hands literally dripped to the floor with sweat, not due to nerves but because of the hyperhydrosis. Read More Hyperhidrosis Testimonials From Around the World
Hyperhidrosis is a physical condition caused by excessive sweating in the body. Hyperhidrosis is caused due to malfunctioning of the sympathetic nervous system or disorders of the sweat glands. Curesweatyplams provides the best excessive perspiration treatment. Though excessive sweating causes are many the primary causes are still unknown and the secondary causes range from anxiety, obesity and psychological tension. Hyperhidrosis symptoms can be dripping sweat, odor along with sweat, stained clothes due to sweat and inferiority complex due to sweat. There are many types of hyperhidrosis like palmer hyperhidrosis, excessive foot sweating, severe underarm sweating and facial hyperhidrosis. Hyperhidrosis can occur at any age. Normally excessive sweating problem occurs after adolescence but there is surgery to stop sweating, which is described at curesweatypalms. Hyperhidrosis medication at an older age is tougher as many other things have to be kept in mind like blood pressure, allergies and resistance. Hyperhidrosis or profuse sweating can be cured with BOTOX injection and Drysol but these medicinal treatments for hyperhidrosis cannot undo the physiological damage that it does to an individual. Excessive perspiration leads the sufferer to isolate from social gatherings and meeting people to avoid embarrassment. Girls sweating or women’s sweaty feet normally cause them a lot of shame.Excess armpit sweating can be treated with hyperhidrosis medication like iontophoresis, sympathectomy, thoracic surgery, botox cosmetic and drysol. Botox is Botulinum Toxin of Type A and is commonly used as treatment fro excessive sweating. Though drysol is also a remedy for hyperhidrosis but there are side effects of drysol which many it a bit less popular and hyperhidrosis botox are named together. Many people suffer from hyperhidrosis like profuse facial sweating, armpit sweating, sweating armpits, sweating at night. They are mostly those who work as speaker or those who address a big audience. On the whole anybody can suffer from hyperhidrosis but those people who are under constant anxiety and tension are at more risk. Jobs like those of models, television personalities, chefs, executives, attorneys, and salesmen are seen to be suffering from intense sweating. These people should refer to curesweatyplams and take treatments for hyperhidrosis like hyperhidrosis surgery, thoracic surgery procedure and surgery for sweaty hands. The maximum population suffers from underarm sweating, which is also called axillary hyperhidrosis. Many people log on to curesweatyplams and say stop sweating under the arms or stop my underarm sweating. Sweaty underarms can be cured but the worst hit are those who have excessive armpit sweating along with a bad odor. But curesweatyplams gives information on surgery to stop sweating. Though sometimes the skin from which the sweat glands are removed or treated reacts to the medicine but it heals with time. Overactive sweat glands can be cured at any age but a proper qualified doctor should be consulted and curesweatyplamsprovides you with all the essential information. Sweaty hands and feet are a big problem and cause much stress but if treated properly can be cured permanently. You need the best and curesweatyplams is the best in dealing with hyperhidrosis.

GENERAL INFORMATION
Home Q&A Questionnaire Payment Methods Testimonials Disclaimer FAQ

CONTACT US
Email Us Our Address Local Direction Local Accommodations Local Attractions

SURGEON'S PROFILE
Doctor Baumgartner Memberships Curriculum Vitae Appointment Hospital Affiliation Bibliography Books And Book Chapters Abstracts Presented & Published

HYPERHIDROSIS INFORMATION
Hyperhidrosis Symptoms of hyperhidrosis Axillary Hyperhidrosis Palmar Hyperhidrosis Plantar Hyperhidrosis Medical Treatment Surgical Technique Surgical Preparation Post Operative Results Side Effects Complications Surgical Sweating Treatment Procedure ETS Surgical Preparation Post Operative Hyperhydrosis Results Side Effects Complications

BROCHURES
Request Form Brochures in Spanish Brochures in Vietnamese

ARTICLES
Severe Hyperhidrosis Read more hyperhidrosis article

HYPERHIDROSIS OR EXCESSIVE SWEATING
What is hyperhidrosis Where does hyperhidrosis occur What are the symptoms of hyperhidrosis What are the alternative treatments for hyperhidrosis Is there a surgical treatment for hyperhidrosis

LINKS
1 Cosmetic Surgery Center Control Excessive Sweating The Cure Foot Pain Center Cure Hand Pain Center Cure Hyperhidrosis Center The Center For Lover-For-Life Hemorrhoid Treatment Center Woman Wellness Center The Hyperhidrosis Center Doctor's Outpatient Surgery Center The Veins Treatment Center

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Thursday, March 5, 2009